Bone Morphogenetic Proteins Poised to Prove Propitious in Orthopedic Care

Bone morphogenetic proteins (BMPs) first came into existence in 1965 and were identified by Marshall Urist. These proteins are responsible for stimulating natural bone growth in the human body. They already exist in the body and can be concentrated, produced, or placed around the spine for spinal fusion. These proteins have the ability to create a fusion without the patient’s own bones. 

What are the various capabilities of BMPs that have facilitated their use?

Amongst the various types of BMPs, BMP-7 and BMP-2 have exhibited the highest ability for cell stimulation in the local environment for undergoing phenotypic conversion into osteoprogenitor cells, which are capable of bone formation. BMPs have been functioning via a number of pathways, including initiating an increase in the secretion of parathyroid hormone and alkaline phosphatase, raising osetocalcin expression, which in turn increases the number of bone-forming cells.

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What is the role of BMPs in spinal fusion?

Conventionally, spinal fusion needed transplantation of bone chips from the pelvis of the patient to the vertebrae to aide in fusing them together. Though this procedure could be extremely effective for treating specific spinal disorders, this bone transplantation procedure, also known as bone grafting, may prolong surgery, increase the hospital stay, cause greater blood loss, and raise the recovery time and pain during recovery. Additionally, the bone grafting technique may result in an unsuccessful vertebral fusion, in which sometimes there is insufficient bone growth.

As per the current innovative research, genetically produced bones and recombinant human bone morphogenetic protein-2 have the cell-stimulating ability of a patient's own cells for making more bone. In addition, rhBMP-2 provides a lot of benefits to patients who are undergoing spinal fusion by eradicating the requirement for bone transplantation through the pelvis. Therefore, this developed therapeutic approach decreases the requirement for depending on screws or spinal rods, expedites the vertebral fusion, and reduces the requirement for painful autograft surgery.

What are the key factors fuelling the global bone morphogenetic protein market?

The increasing occurrence of spinal fusion surgeries and colon cancer is predicted to stimulate the global market for bone morphogenetic protein (BMP) during the forecast period. Huge R&D investment along with the emergence of novel devices and drugs used in orthopedic conditions are anticipated to provide bones that are functionally stronger and will heal damaged bones comparatively quickly.

The rising geriatric population, increase in sports- and trauma-related injuries, and increase in the demand for minimal invasive surgeries are predicted to fuel the growth of the bone morphogenetic protein market in the forecast horizon. In addition, increasing disorders of the lower back due to the changing modern lifestyle is expected to raise demand for spinal surgeries, which will boost the bone morphogenetic proteins market. 

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Thousands of bone fusion operations are performed in the U.S. annually, greater than halfmore than half of which comprise spinal column fusion. Therefore, one of the biggest challenges to orthopedic research has been the requirement for novel ways to repair bones faster and make them functionally stronger through organic means, wherein bone morphogenetic proteins have emerged as a highly promising solution. 

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